Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from rat insulinoma INS-1 cells under glucotoxic condition

ABSTRACT: Glucotoxicity of INS-1 cells stimulation by chronic high glucose. We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of up and down-regulated genes during this process.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE113828 | GEO | 2018/05/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data from rat insulinoma INS-1 cells under glucotoxic condition

Project description:Expression data from rat insulinoma INS-1 cells under glucotoxic condition

| PRJNA454198 | ENA

sRNA sequencing of miRNAs exported to HDL from INS-1 rat insulinoma cells

Project description:miRNAs are exported to high density lipoproteins (HDL). This study aimed to understand what miRNAs are exported from INS-1 cells to HDL in vitro.

2019-01-16 | GSE125135 | GEO

Transcription profiling of rat insulinoma INS-1 cell lines (FLP-In T-REx)

Project description:Four rat insulinoma cell lines (INS-1) were generated that contain a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the cell lines contain the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene expression profiles of uninduced and tet-induced cells, target genes of introduced transcription factors or other signal tranduction molecules can be identified. The expression profiles of the parental INS-1 cell line and the four derivatives were determined on a RAE230A array, showing that the highly differentiated phenotype of the parental cell line was maintained in the clones.

2008-06-11 | E-GEOD-1591 | biostudies-arrayexpress

Transcription profiling of rat insulinoma (INS-1 derived) cells grown in lipid culture

Project description:This experiment was designed to study the effects of lipid culture on INS-1 derived glucose-responsive 832/13 cells. After 48-hr culture with lipids, a dramatic decrease in glucose-responsiveness is observed. In order to detect some earlier changes, RNA was also collected at earlier time points (12 hr and 24 hr). To compensate for any changes associated with cell density, control cells (1%BSA culture) were included for each time point. RNA was prepared from INS-1 cells in Dr. Chris Newgard's lab, quantified and sent frozen in water. Six biological replicates were sent for the following conditions: (i) 1%BSA (12, 24, and 48 hours) (ii) 1mM-Oleate/Palmitate (12, 24, and 48 hours).

2007-09-11 | E-CBIL-34 | biostudies-arrayexpress

Transcription profiling of rat insulinoma line INS-1 to identify targets of HNF1b mutants in INS-1

Project description:A rat insulinoma cell line (INS-1) was generated that contains a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the line contains the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene expression profiles of uninduced and tet-induced cells, target genes of introduced transcription factors HNF1b and HNF1b mutants were identified. Two different clones containing the same transcription factor were analyzed in the non-induced and tet-induced (24 h) state.

2008-06-11 | E-GEOD-1590 | biostudies-arrayexpress

Expression data from early rice endosperm

Project description:We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of regulated genes during this process.

2015-09-01 | GSE57615 | GEO

Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells.

Project description: Not available

| S-EPMC7683504 | biostudies-literature

Transcription profiling of rat insulinoma (INS-1 derived) cell lines that vary in their glucose responsiveness

Project description:The aim of this study was to identify the gene expression changes associated with glucose responsiveness in Rat INS-1 derived cell lines. RNA was prepared from cell lines which were shown to be highly glucose responsive and also lines which were shown to be poorly glucose responsive. Dr. Chris Newgard's lab quantified the RNA and sent it frozen in water. 3 biological replicates per condition were sent for the following conditions: (i) 832/13 and 833/15, robust glucose responsiveness; (ii)832/1 and 832/2 showed poor glucose responsiveness.

2007-09-11 | E-CBIL-35 | biostudies-arrayexpress

Expression data from early rice endosperm

Project description:We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of regulated genes during this process. Rice endosperm at 2 days after pollination(DAP) was selected for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the endosperm expression profile at 2 DAP. To that end, we hand-selected endosperm according to morphological criteria at 2 DAP before cellularization.

2015-09-01 | E-GEOD-57615 | biostudies-arrayexpress

sRNA sequencing of miRNAs exported to HDL from INS-1 rat insulinoma cells

Project description:sRNA sequencing of miRNAs exported to HDL from INS-1 rat insulinoma cells

| PRJNA515308 | ENA