Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development

ABSTRACT: Jarid2 cooperates with PRC2 for H3K27me3 accumulation on a subset of Jarid2 target genes in the developing heart, which contributes to repress differentiation of other lineages such as neural differentiation, and to guide normal myocardial development. Jarid2 forms a functional complex with PRC2 to increase or maintain H3K27me3 levels on the specific promoters in the developing heart.

ORGANISM(S): Mus musculus

PROVIDER: GSE113895 | GEO | 2018/05/02

REPOSITORIES: GEO