Expression data from tumor samples treated with a tankyrase inhibitor in a mouse xenograft model

ABSTRACT: Tankyrase enhances beta-catenin signaling via PARsylation and subsequent degradation of Axin, a negative regulator of beta-catenin. Tankyrase inhibitors stabilize Axin and suppress beta-catenin signaling. We developed a novel tankyrase inhibitor, RK-287107. We used microarrays to elucidate the gene expression profile of human colorectal cancer cells treated with RK-287107 in a mouse xenograft model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113965 | GEO | 2018/12/26

REPOSITORIES: GEO