ChIP-seq data for H3K27 acetylation from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

ABSTRACT: We found genetic deletion of IKKβ in mdx cardiomyocytes improved cardiac function and normalized calcium transients, and that differential gene expression favored a repressive function for NF-[kappa]B in these mice. We suspected that NF-[kappa]B was conferring a more restrictive chromatin conformation in a subset of genes. ChIP-seq was performed for H3K27 acetylation to show this repressive function for NF-[kappa]B was a global effect and to identify specific genes with more permissive chromatin conformation in hearts of mdx mice with IKKβ-deficient cardiomyocytes compared to mdx mice with intact IKKβ signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE114023 | GEO | 2018/06/14

REPOSITORIES: GEO