Drosophila CNS mitochondrial dysfunction with Ras/MAPK inhibition microarray

ABSTRACT: Mitochondrial dysfunction causes biophysical, metabolic and signalling changes that alter homeostasis and reprogram cells. We used a Drosophila model in which TFAM is overexpressed in the nervous system with or without Ras/MAPK pathway inhibition, by knock-down of the ETS transcription factor pointed, to investigate the how mitochondrial dysfunction and Ras/MAPK signalling affect the transcriptome. We used microarray analysis to investigate gene expression in cases of mitochondrial dysfunction in the CNS with or without Ras/MAPK pathway inhibition by knock-down of pointed (Pnt) and anterior open (Aop).

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE114054 | GEO | 2018/05/05

REPOSITORIES: GEO