Expression profile of MESH1 and ATF4 silencing RCC4 cells

ABSTRACT: MESH1 encodes for Metazoan SpoT Homolog 1, which is a homologue of bacterial SpoT that mediates bacterial stringent response. In human cells, we found that MESH1-silencing induces an extensive transcriptional response in clear cell carcinoma cell line RCC4 that partially overlap with mammalian cell integrated stress response (ISR), which ATF4 up-regulation is an essential branch of the response. In this study, the goal is to elucidate the role of ATF4 up-regulation in MESH1-silencing transcriptional response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114128 | GEO | 2021/07/30

REPOSITORIES: GEO