Chromosome copy number and LOH analysis of colorectal carcinoma specimens

ABSTRACT: Structural changes of chromosomes play important roles in the carcinogenesis of colorectal carcinoma (CRC). Here, by using SNP-typing arrays, we have tried to screen for recurrent chromosome copy number changes and loss-of-heterozygosity in the genome of colorectal carcinoma. Genomic DNA was isolated from tumor and paired normal tissues of CRC (n=94), and was hybridized to Affymetrix Mapping 50K Xba 240 arrays. Chromosome copy number and LOH likelihood score was inferred at every SNP locus with CNAG2.0 software (http://www.genome.umin.jp). Keywords: Comparative genomic hybridization

ORGANISM(S): Homo sapiens

PROVIDER: GSE11417 | GEO | 2008/08/21

SECONDARY ACCESSION(S): PRJNA106431

REPOSITORIES: GEO