Modulation of medaka transcriptome by trametinib and cisplatin

ABSTRACT: We employed a transgenic strain of a small aquarium fish medaka (Oryzias latipes) that overexpresses a malignant melanoma driver gene. In this model, melanoma develops with 100 % penetrance. Using the medaka malignant melanoma model, we tested whether cisplatin and trametinib are able to suppress the transcriptomic changes induced by the transgene.

ORGANISM(S): Oryzias latipes

PROVIDER: GSE114190 | GEO | 2021/05/18

REPOSITORIES: GEO