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Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [Agilent]

ABSTRACT: Purpose: To understand how gene expression changes in yan and pnt mutant embryos

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE114208 | GEO | 2018/05/08

REPOSITORIES: GEO

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Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [ChIP-Seq]

Project description:Purpose: To understand how the Drosophila ETS transcription factors Yan and Pointed together with the corepressor Groucho are recruited to chromatin

2018-05-08 | GSE114092 | GEO

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.

Project description: Not available

| S-EPMC6053666 | biostudies-literature

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-08 | GSE114209 | GEO

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila

Project description:Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila

| PRJNA470552 | ENA

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [Agilent]

Project description:Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [Agilent]

| PRJNA470554 | ENA

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [ChIP-Seq]

Project description:Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila [ChIP-Seq]

| PRJNA464289 | ENA

Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.

Project description: Not available

| S-EPMC5900712 | biostudies-literature

Genome-Wide Yan Chromatin Occupancy in Drosophila Embryos

Project description:The ETS transcriptional repressor Yan functions as part of a developmental switch that in response to receptor tyrosine kinase signaling, transitions from a high-Yan to a low-Yan state to direct specification of a variety of cell fates. To date very few direct target genes have been identified, nor is it clear how their expression is buffered against developmental noise to prevent inappropriate oscillations between states. Following investigation of its genome-wide chromatin occupancy profile, we noticed a striking signature at developmentally important genes whereby Yan associates with chromatin in regions of high-peak density that span multiple kilobases which partially relies upon SAM-domain mediated self-association. We speculate that the high-density Yan occupancy signature may reveal a novel mechanism that buffers the expression of critical developmental regulators against intrinsic and environmental noise. The supplementary bed file contains Yan binding regions. Yan ChIP from staged Drosophila embryos

2013-03-01 | E-GEOD-34038 | biostudies-arrayexpress

Genome-Wide Yan Chromatin Occupancy in Drosophila Embryos

2013-03-01 | GSE34038 | GEO

Genome-wide maps of Yan chromatin association

Project description:High-resolution genome-wide binding of Yan used to confirm the presence of high-density regions seen in ChIP-chip ChIP-Seq of Yan protein in stage 11 Drosophila embryos

2013-03-01 | E-GEOD-34040 | biostudies-arrayexpress

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