Ontology highlight
ABSTRACT:
INSTRUMENT(S): Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version)
ORGANISM(S): Mus Musculus
SUBMITTER: Ya-Ping Yen
PROVIDER: GSE114228 | GEO | 2018-11-01
REPOSITORIES: GEO
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Yen Ya-Ping YP Hsieh Wen-Fu WF Tsai Ya-Yin YY Lu Ya-Lin YL Liau Ee Shan ES Hsu Ho-Chiang HC Chen Yen-Chung YC Liu Ting-Chun TC Chang Mien M Li Joye J Lin Shau-Ping SP Hung Jui-Hung JH Chen Jun-An JA
eLife 20181012
The mammalian imprinted Dlk1-Dio3 locus produces multiple long non-coding RNAs (lncRNAs) from the maternally inherited allele, including Meg3 (i.e., Gtl2) in the mammalian genome. Although this locus has well-characterized functions in stem cell and tumor contexts, its role during neural development is unknown. By profiling cell types at each stage of embryonic stem cell-derived motor neurons (ESC~MNs) that recapitulate spinal cord development, we uncovered that lncRNAs expressed from the Dlk1-D ...[more]