Single cell paired heavy- and light-chain immunoglobulin sequencing of sorted Lyme disease plasmablasts

ABSTRACT: Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity world-wide. Here, we investigated B cell responses to Lyme disease through barcode-enabled single cell sequencing of activated B cells (plasmablasts) sorted from PBMCs. Bulk immunglobulin heavy-chain sequencing from this project has also been separately deposited. Additional information regarding patient characteristics and overlap with other data from the SLICE study is available upon request.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114309 | GEO | 2018/12/21

REPOSITORIES: GEO