Transcriptomics,Genomics

Dataset Information

32

Expression data from NPY Y1R-deficient osteoblastic cells


ABSTRACT: NPY signalling via osteoblastic Y1 receptors has been shown to control bone mass but also contributes significantly to the control of whole-body insulin secretion and glucose homeostasis in mice through the release of novel factor(s) which are different from the previously implicated osteocalcin. We used microarrays to identify novel endocrine factors regulated by Y1 receptors and involved in the regulation of bone mass and whole-body homeostasis. Overall design: Microarrays were performed on GFP-positive osteoblastic cells isolated from either WT (n=4) or Y1-deficient mice (n=2) expressing GFP under control of a 3.6kb fragment of the rat alpha1(I)-collagen promotorand the data were analysed for

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Nicola J Lee  

PROVIDER: GSE114469 | GEO | 2018-05-16

REPOSITORIES: GEO

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Publications

Osteoglycin, a novel coordinator of bone and glucose homeostasis.

Lee N J NJ   Ali N N   Zhang L L   Qi Y Y   Clarke I I   Enriquez R F RF   Brzozowska M M   Lee I C IC   Rogers M J MJ   Laybutt D R DR   Center J R JR   Baldock P A PA   Herzog H H  

Molecular metabolism 20180508


OBJECTIVE:The skeleton, which is strongly controlled by endocrine factors, has recently been shown to also play an active endocrine role itself, specifically influencing energy metabolism. However, much less is known about this role. Therefore, we sought to identify novel endocrine factors involved in the regulation of both bone mass and whole-body glucose homeostasis. METHODS:We used transcriptomic and proteomic analysis of Y1 receptor deficient osteoblasts combined with the generation of a nov  ...[more]

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