Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

ABSTRACT: Integrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide retention of cassette exons bearing cytosine(C)-rich sequences.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE114502 | GEO | 2020/03/12

REPOSITORIES: GEO