Global chromatin accessibility of gene locus in CD4+ T cells activated with or without OX40 costimulation

ABSTRACT: OX40 is a T cell costimulatory molecule in the tumor necrosis factor receptor (TNFR) superfamily. Unlike other costimulatory molecules, OX40 is not expressed by naive T cells, but its expression is rapidly induced following T cell activation, and OX40 costimulation plays a critical role in cell survival, proliferation, and generation of memory cells. We used ATAC-seq to detail the chromatin accessibility of gene locus of activated CD4 T cells with or without OX40 costimulation in the presence of TGF-β1 and IL-2 and identified distinct classes of genes after OX40 costimulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE114568 | GEO | 2018/05/18

REPOSITORIES: GEO