Transcriptomics,Genomics

Dataset Information

42

Transcriptional control of adipose tissue macrophages during high-fat diet-induced obesity.


ABSTRACT: We used transcriptome microarrays to identify gene expression changes in macrophages isolated from adipose tissue of lean and obese mice. Overall design: F4/80+ adipose tissue macrophages were isolated from epididymal fat of mice fed normal chow diet (NCD, lean mice) or 60% high-fat diet (HFD, obese mice) for 16 weeks.

INSTRUMENT(S): [MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]

SUBMITTER: Mitzi Nagarkatti  

PROVIDER: GSE114735 | GEO | 2018-05-22

REPOSITORIES: GEO

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Publications

MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages.

Miranda Kathryn K   Yang Xiaoming X   Bam Marpe M   Murphy E Angela EA   Nagarkatti Prakash S PS   Nagarkatti Mitzi M  

International journal of obesity (2005) 20180613 6


BACKGROUND/OBJECTIVES:Obesity is a pandemic disorder that is characterized by accumulation of adipose tissue and chronic low-grade inflammation that is driven primarily by adipose tissue macrophages (ATMs). While ATM polarization from pro-(M1) to anti-(M2) inflammatory phenotype influences insulin sensitivity and energy expenditure, the mechanisms of such a switch are unclear. In the current study, we identified epigenetic pathways including microRNAs (miR) in ATMs that regulate obesity-induced  ...[more]

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