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Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cells treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity

ABSTRACT: Microarray whole-transcriptome profiling in HCT116 and HepG2 cells treated with Melicope ptelefolia leaf extract reveals transcriptome profles exhibiting anticancer activity

ORGANISM(S): Homo sapiens

PROVIDER: GSE114743 | GEO | 2018/06/21

REPOSITORIES: GEO

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Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cells treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity

Project description:Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cells treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity

| PRJNA472458 | ENA

Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cell lines treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity.

Project description: Not available

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Anti-cancer activity of Cotyledon orbiculata extract

Project description:We investigated the effects of the crude extract of a South African medicinal plant, Cotyledon orbiculata, on cell survival of colon (HCT116) cancer cell lines. Using RNASeq, we discovered that the extract interfered with mRNA regulatory pathways. Here, we found that the extract of Cotyledon orbiculata, a South African medicinal plant, had an anti-proliferative effect in cancer cells, mediated by apoptosis induced by alternative splicing of hnRNPA2B1 and BCL2L1.

2020-10-06 | GSE156221 | GEO

Transcript Level Expression Profiling: anticancer pathways of Smilax Glabra rhizome extract (SW) [HepG2 cells]

Project description:To find the possible signaling pathways which contribute to the anticancer effect of SW-treated HepG2 cells Global gene expression profiling is an ideal technique to obtain useful clues for exploration of the anticancer mechanism of SW. Through comparing microarray results between solvent- and SW-treated cells, differentially expressed genes were obtained (>1.5 fold). The microarray results were validated using real-time RT-PCR. We used the KEGG database, STRING database and GO database for further ananlysis, and therefore got the possible signaling pathways underlying the anticancer effect of SW. We analyzed total RNA samples of solvent- and SW-treated HepG2 cells using the Affymetrix Human Gene 1.0 ST platform. No techinical replicates were performed.

2014-06-08 | E-GEOD-58201 | biostudies-arrayexpress

Transcript Level Expression Profiling: anticancer pathways of Smilax Glabra rhizome extract (SW)

Project description:Find the possible signaling pathways which contribute to the cell growth inhibition effect of SW-treated AGS cells Global gene expression profiling is an ideal technique to obtain useful clues for exploration of the anticancer mechanism of SW. Through comparing microarray results between solvent- and SW-treated cells, differentially expressed genes were obtained (>1.5 fold). The microarray results were validated using real-time RT-PCR. We used the KEGG database, STRING database and GO database for further ananlysis, and therefore got the possible signaling pathways underlying the anticancer effect of SW. We analyzed total RNA samples of solvent- and SW-treated AGS cells using the Affymetrix Human Gene 1.0 ST platform. No techinical replicates were performed.

2014-04-09 | E-GEOD-56593 | biostudies-arrayexpress

P. syringae pv. phaseolicola NPS3121 responses to bean leaf extract

Project description:Many genes involve in pathogenicity and virulence are induced only in plant or in the presence of host components. Bean leaf extract was obtained from healthy bean leaves. In this work we investigated the effect of bean leaf extract on the transcriptomic profile of the bacterium, when grown at low temperature in minimal medium with or without extract from healthy bean leaves.

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Transcript Level Expression Profiling: anticancer pathways of Smilax Glabra rhizome extract (SW) [HepG2 cells]

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Transcript Level Expression Profiling: anticancer pathways of Smilax Glabra rhizome extract (SW)

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Modulation of apple leaf trancriptome by tomato cutin monomer extract

Project description:Investigation of whole genome gene expression level changes in leaves of apple seedlings (Golden delicious) 3 days after treatment by tomato cutin monomer extract (CME) versus formulation blank (FB). CME is a formulated extract enriched of hydroxy fatty acids from tomato cuticle

2024-02-09 | GSE245564 | GEO

RNAi of signal transduction components in HCT116 cells

Project description:We performed RNAi knockdown experiments on 7 different signal transduction components of the Wnt pathway in HCT116 colon cancer cells and prepared RNA libraries from the poly-adenylated fraction of the RNA. SOLiD sequencing of strand-specific, barcoded transcriptome libraries yielded expression profiles allowing us to extract common pathway signatures and enabeling us to perform susequent nested effects modelling. the resulting pathway models yields new insight in the pathway topology in colon cancer.

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