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UGA Folic acid supplementation in pregnant women

ABSTRACT: DNA samples were derived from maternal blood collected during a baseline prenatal visit and at delivery.

ORGANISM(S): Homo sapiens

PROVIDER: GSE114935 | GEO | 2018/06/25

REPOSITORIES: GEO

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UGA Folic acid supplementation in pregnant women

Project description:UGA Folic acid supplementation in pregnant women

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Folate of pregnant women after a nationwide folic acid supplementation in China.

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Sex-specific changes of placental transcriptome in response to a n-3 LCPUFA supplementation of pregnant women

Project description:Previously, we have examined the effect of maternal dietary n-3 LCPUFA supplementation during pregnancy to reduce offspring obesity risk. Considering the involvement of the placenta in fetal programming, we here analyzed the sexually dimorphic potential of placental gene expression, its response to the n-3 LCPUFA intervention and their correlation to offspring obesity risk. The placenta is implicated to play a key role in mediating fetal /metabolic programming of the offspring in utero. For human and mouse models, it has been reported that male and female fetuses differentially respond to in utero environmental stimuli. Moreover, sexual dimorphism is also known for placental gene expression, LCPUFA metabolism and adipose tissue distribution. Therefore, we explored whether the maternal n-3 LCPUFA intervention during pregnancy has a sex-specific impact on the term placental transcriptome in a defined subpopulation of the INFAT (impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development) study. In addition, we assessed the relationships between sex-specific placental gene expression and sex steroids levels, and expression changes of specific genes and offspring obesity risk. Overall, human term placentas show sexually dimorphic gene expression and respond sex-specifically to dietary maternal n-3 LCPUFA intervention during pregnancy with more pronounced effects on gene expression and estradiol-17β/testosterone ratio in female than male placentas.

2014-10-30 | GSE53291 | GEO

Adherence to iron-folic acid supplementation among pregnant women in Ethiopia: a systematic review and meta-analysis.

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Adherence to Iron-Folic Acid Supplementation and Associated Factors among Pregnant Women in Kasulu Communities in North-Western Tanzania.

Project description: Not available

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Magnitude and factors associated with adherence to Iron-folic acid supplementation among pregnant women in Eritrean refugee camps, northern Ethiopia.

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UGA Folate and Pregnancy

Project description:Umbilical cord blood was collected from live deliveries at the Athens Regional Midwifery Clinic. Neonatal sex, race and gestational age was obtained by review of the delivery records.

2016-04-19 | GSE80310 | GEO

Counselling and knowledge on iron and folic acid supplementation (IFAS) among pregnant women in Kiambu County, Kenya: a cross-sectional study.

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Maternal folic acid supplementation alters gene expression in the offspring brain

2013-09-09 | GSE45607 | GEO

Maternal folic acid supplementation alters gene expression in the offspring brain

Project description:Studies have indicated that altered maternal micronutrients and vitamins influence the development and susceptibility of newborns to chronic diseases. Among these, folic acid (FA) plays a key role in the synthesis and repair of DNA, along with maintenance of epigenetic DNA methylation. Deficiency of FA has been associated with the pathogenesis of neural tube defects. Since FA can modulate DNA methylation and affect gene expression, we investigated the effect of gestational FA supplementation on the expression of genes in the offspring brain. Our results suggest that a maternal ten-fold increase in FA supplementation alters the expression and dysregulates a number of genes in the offspring brain, including many involved in development. While a number of genes that were dysregulated were common to both male and female pups, there were sex differences in gene expression changes. C57BL/6J female mice were separated into two groups of ten mice and supplemented with a custom diet. One week prior to mating the low-dose group of female mice were fed a custom AIN-93G amino acidM-bM-^@M-^Sbased diet (Research Diet, Inc. New-Brunswick, NJ), with FA at 0.4 mg/kg, while the high-dose group received FA at 4 mg/kg diet. Tissues from the cerebral hemisphere of three independent pups of same gender were pooled together. A total of three microarray gene expression studies have been performed (0.4mg/kg or 4mg/kg both male and female) and the mean was used for comparison.

2013-09-09 | E-GEOD-45607 | biostudies-arrayexpress

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