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Adipocyte-derived lipids mediate melanoma progression via FATP proteins

ABSTRACT: We performed RNA-seq on A375 melanoma cells in monoculture or after coculture with adipocytes and identified differentially expressed genes

ORGANISM(S): Homo sapiens

PROVIDER: GSE114941 | GEO | 2018/05/26

REPOSITORIES: GEO

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Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins.

Project description: Not available

| S-EPMC6192670 | biostudies-literature

Adipocyte-derived lipids mediate melanoma progression via FATP proteins

Project description:Adipocyte-derived lipids mediate melanoma progression via FATP proteins

| PRJNA473164 | ENA

Comparative transcriptional analysis of Desulfovibrio alaskensis G20 grown under various syntrophic and fermentative conditions on pyruvate relative to respiratory growth

Project description:Pyruvate fermentation pathway and energetics of Desulfovibrio alaskensis strain G20 under syntrophic coculture and fermentative monoculture conditions Expression data for Desulfovibrio alaskensis strain G20 grown in chemostats on pyruvate under respiratory conditions (sulfate-limited and pyruvate-limited monoculture, dilution rate 0.047 and 0.027 h-1), fermentative conditions (monoculture, dilution rate 0.036 h-1), and syntrophic conditions (coculture with Methanococcus maripaludis or Methanospirillum hungatei, dilution rate of 0.047 and 0.027 h-1) 2 replicates each for syntrophic coculture (M. maripaludis or M. hungatei pairing) and respiratory (sulfate- or pyruvate-limited) monoculture for both growth rates (0.027 and 0.047 h-1), and 4 replicates fermentative monoculture (gas flow rate through head space of bioreactor 10 ml/min (chemostats C91 and C93) or 1 ml/min (chemostats C92 and C94)

2013-12-12 | E-GEOD-53226 | biostudies-arrayexpress

Comparative transcriptional analysis of Desulfovibrio G20 grown under syntrophic and respiratory condtions

2012-11-29 | E-GEOD-42571 | biostudies-arrayexpress

Comparative transcriptional analysis of Desulfovibrio alaskensis G20 grown under various syntrophic and fermentative conditions on pyruvate relative to respiratory growth

2013-12-12 | GSE53226 | GEO

Influence of growth rate and methanogenic partner on syntrophic metabolism of Desulfovibrio G20 (comparative transcriptional analysis of Desulfovibrio G20 grown under various syntrophic conditions relative to respiratory growth)

Project description:Expression data for Desulfovibrio alaskensis strain G20 grown on lactate in sulfate-limited monoculture and syntrophic coculture with Methanococcus maripaludis or Methanospirillum hungatei in chemostats at a low growth rate of 0.027h-1. 7 samples of Desulfovibrio alaskensis strain G20 grown in syntrophic coculture on lactate with either Methanococcus maripaludis (4 replicates) or Methanospirillum hungatei (3 replicates), and 5 samples of sulfate-limited monoculture growth of strain G20 on lactate.

2013-05-02 | E-GEOD-46547 | biostudies-arrayexpress

Stem cell coculture

Project description:This study aims to to compare the gene transcription profiles of endothelial cells and stem cells, when they are cultured alone or when they are cultured together. Thus there are two major questions - how do the cells differ, and how do the cells influence each other's gene expression. Thus there are 4 types of sample: endothelial cell monoculture, endothelial cell coculture, stem cells monoculture, stem cell coculture. There are also 4 biological replicates (independent experiments) leading to 16 array data files.

2013-10-10 | E-MTAB-1536 | biostudies-arrayexpress

Gene expression of H. parainfluenzae in monoculture and coculture with S. mitis

Project description:Identify DEGs in H. parainfluenzae in monoculture vs coculture with S. mitis aerobically on BHI-YE HP at 37.C and 5% CO2

2020-12-31 | GSE158845 | GEO

Multi-walled carbon nanotube-induced gene expression in vitro

Project description:There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study compared global multi-walled carbon nanotube (MWCNT)-induced gene expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with gene expression from mouse lungs exposed to MWCNT. Using a cutoff of 10% false discovery rate and 1.5 fold change, we determined that there were more concordant genes (gene expression both up- or downregulated in vivo and in vitro) expressed in both cell types in coculture than in monoculture. When reduced to only those genes involved in inflammation and fibrosis, known outcomes of in vivo MWCNT exposure, there were more disease-related concordant genes expressed in coculture than monoculture. Additionally, different cellular signaling pathways are activated in response to MWCNT dependent upon culturing conditions. As coculture gene expression better correlated with in vivo gene expression, we suggest that cellular cocultures may offer enhanced in vitro models for nanoparticle risk assessment and the reduction of in vivo toxicological testing.

2019-04-12 | GSE129640 | GEO

Comparative transcriptional analysis of Desulfovibrio G20 grown under syntrophic and respiratory condtions

2012-11-29 | GSE42571 | GEO

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