Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE114993 | GEO | 2018/12/14

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Project description: Not available

| S-EPMC6355374 | biostudies-literature

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

Project description:Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in mouse DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

2018-12-14 | GSE118452 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

2018-12-14 | GSE114992 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

2018-12-14 | GSE114991 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

| PRJNA473488 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

| PRJNA473490 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

| PRJNA473491 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

| PRJNA485698 | ENA

West Nile virus infection of human monocyte-derived dendritic cells

Project description:West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cells (DCs) in priming WNV-specific T cell immunity remains poorly understood. Here, we demonstrate that human monocyte derived DCs (moDCs) support productive viral replication following infection with a pathogenic strain of WNV. Antiviral effector gene transcription was strongly induced during the log-phase viral growth, while secretion of type I interferons (IFN) occurred with delayed kinetics. Activation of RIG-I like receptor (RLR) or type I IFN signaling prior to log-phase viral growth significantly diminished viral replication, suggesting that early activation of antiviral programs can block WNV infection. In contrast to the induction of antiviral responses, WNV infection did not promote transcription or secretion of pro-inflammatory (IL-6, GM-CSF, CCL3, CCL5, CXCL9) or T cell modulatory cytokines (IL-4, IL-12, IL-15). There was also minimal induction of molecules associated with antigen presentation and T cell priming, including the co-stimulatory molecules CD80, CD86, and CD40. Functionally, WNV-infected moDCs dampened allogenic CD4 and CD8 T cell activation and proliferation. Combined, we propose a model where WNV subverts human DC activation to compromise priming of WNV-specific T cell immunity.

2019-09-06 | GSE136342 | GEO

gammadelta T cells promote the maturation of dendritic cells during West Nile virus infection.

Project description: Not available

| S-EPMC2954433 | biostudies-literature