Estrogen responsive transcriptome of estrogen receptor positive normal human breast cells in 3D cultures

ABSTRACT: Understanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We developed a 3D culture model that enables the propagation of normal estrogen receptor alpha (ER)+ cells. The purpose of this experiment was to assess ER functionality and compare estrogen-induced transcripts among samples and systems.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115112 | GEO | 2018/06/15

REPOSITORIES: GEO