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The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

ABSTRACT: Orexin A belongs to the group of hypothalamic-derived peptides that are involved in a number of processes, such as regulation of energy metabolism, control of food intake and regulation of the reproductive system. Orexin A is also expressed in the endometrium, myometrium and placenta, which suggests that it may act as an important local regulator of the reproductive functions. The aim of this study was to explore the influence of orexin A on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

ORGANISM(S): Sus scrofa Sus scrofa domesticus

PROVIDER: GSE115195 | GEO | 2018/06/02

REPOSITORIES: GEO

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The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

Project description:Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine myometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122414 | GEO

The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

Project description:Orexins, namely orexin A (OXA) and orexin B (OXB) belongs to the family of neuropeptides produced mainly by specific neurons of the lateral region of the hypothalamus. Primarily orexins were recognized as hormones involved exclusively in the regulation of food intake and energy homeostasis. However, a growing body of evidences indicate their involvement in the regulation of an increasing number of biological processes, inter alia, in the regulation of the reproductive functions. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122415 | GEO

The in vitro influence of adiponectin on the porcine endometrium on days 15 to 16 of gestation.

Project description:Adiponectin is a hormone secreted primarily by white adipose tissue. Recent studies have shown that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in different reproductive tissues, including the ovary and uterus. This newly discovered endocrine system plays an important role in the regulation of reproductive processes. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122400 | GEO

The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

Project description:Orexins belong to the group of metabolism regulating factors connected mainly with the nervous system. Both biologically active neuropeptides, orexin A (OXA) and orexin B (OXB) are products of the proteolytic cleavage of common 130 amino-acid precursor – prepro-orexin (PPO). In the reproductive system orexins has been found to act not only on the endocrine, but also auto- and paracrine manner. In the present study we focused on the effect of OXA treatment on the global gene expression in the porcine myometrium during the most dynamic phase of the early pregnancy – the implantation period (days 15 to 16 of gestation).

2018-11-09 | GSE122310 | GEO

The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

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The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

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The in vitro influence of adiponectin on the porcine myometrium on days 15 to 16 of gestation.

Project description:Adiponectin is secreted by the white adipose tissue and is one of the most important hormones that regulate metabolic homeostasis. The expression of adiponectin and adiponectin receptor genes and proteins in reproductive organs, such as the testes, ovaries and uterus, suggests that adiponectin is also involved in the regulation of reproductive functions. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

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The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

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Gene profiling within the orexin-producing neurons

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RNA sequencing of eutopic endometrium and of myometrium from women with and without diffuse adenomyosis in the proliferative phase of the menstrual cycle

Project description:This study sought to identify potential mechanisms underlying the pathogenesis and pathophysiology of adenomyosis with a focus on the endometrium and myometrium. Transcriptomic profiles of eutopic endometrium and of myometrium from women with and without diffuse adenomyosis were assessed using RNA sequencing.

2023-03-08 | GSE190580 | GEO

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