Transcriptomics

Dataset Information

30

Mild vs advanced liver fibrosis


ABSTRACT: The aim of this study is to compare mild and advanced liver fibrosis gene expression profiling and to identify novel markers of fibrosis progression. By transcriptome analysis with a cDNA array virtually covering every transcript in liver, we compared transcript levels in mild (F1 Metavir score) and advanced (F4 Metavir score) fibrosis. A stringent selection identified a list of 16 transcripts which completely separated the 2 groups of patients (8 F1 and 8 F4). We report that dysregulations at the transcriptional level do exist between mild fibrosis (F1) and advanced fibrosis (F4). Keywords: fibrosis stage-dependent analysis Overall design: Fibrosis samples were analyzed for 16 patients : 8 mild fibrosis (F1-1 to F1-8) and 8 advanced fibrosis (F4-1 to F4-8). All data in the current study were obtained from 3 separate hybridizations per RNA sample.

INSTRUMENT(S): INSERM Homo sapiens 14K array Liverpool3

ORGANISM(S): Homo sapiens  

SUBMITTER: Jean Philippe SALIER  

PROVIDER: GSE11536 | GEO | 2008-05-24

SECONDARY ACCESSION(S): PRJNA106257

REPOSITORIES: GEO

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