Genomics

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Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts


ABSTRACT: CpG methylomic characterization of BDE-47 exposed cultured primary human cytrophoblasts (2nd trimester) undergoing differentiation in vitro. Overall design: CpG methylome of human villous cytotrophoblasts exposed to BDE-47 or DMSO (vehivle control) for 24h; either exposed after attachment (~3h in culture) or following cell-cell aggregation (~15h). Sample processing and hybridization was performed by the UCSF Gladstone Institute

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

SUBMITTER: Joshua F Robinson  

PROVIDER: GSE115399 | GEO | 2018-09-01

REPOSITORIES: GEO

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Publications

Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.

Robinson Joshua F JF   Kapidzic Mirhan M   Hamilton Emily G EG   Chen Hao H   Puckett Kenisha W KW   Zhou Yan Y   Ona Katherine K   Parry Emily E   Wang Yunzhu Y   Park June-Soo JS   Costello Joseph F JF   Fisher Susan J SJ  

Toxicological sciences : an official journal of the Society of Toxicology 20190101 1


Despite gradual legislative efforts to phase out flame retardants (FRs) from the marketplace, polybrominated diphenyl ethers (PBDEs) are still widely detected in human maternal and fetal tissues, eg, placenta, due to their continued global application in consumer goods and inherent biological persistence. Recent studies in rodents and human placental cell lines suggest that PBDEs directly cause placental toxicity. During pregnancy, trophoblasts play key roles in uterine invasion, vascular remode  ...[more]

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