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BRG1 occupancy profiling by high throughput sequencing from control and PTEN knockdown 22RV-1 cells

ABSTRACT: To identify the downstream targets and pathways mediated by BRG1, chromatin immunoprecipitation followed by sequencing (ChIP–seq) was performed in control and PTEN-knockdown 22RV-1 cells. Total 6279 genes showed the enhanced BRG1 occupancies in PTEN-knockdown cells as compared to that in control cells. Genome-wide analysis revealed that PTEN loss lead to increase BRG1 intervals specifically localized at enhancers, but not distal promoter regions. We therefore reasoned ablation of BRG1 might impair enhancer configurations in PTEN-deficient cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115615 | GEO | 2019/01/14

REPOSITORIES: GEO

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