Genome-wide fork-collapse sites in MDA-MB-231 cells from ATR inhibition [human]

ABSTRACT: Transient obstruction of DNA polymerase progression activates the ATR checkpoint kinase, which suppresses fork breakage, strand resection, and RPA accumulation. Herein, we use a developed DNA break-detection assay, BrITL, to identify replication-problematic loci that become processed into persistent double-strand breaks across the human genome from ATR inhibition.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115623 | GEO | 2018/10/04

REPOSITORIES: GEO