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Gene expression analysis of a MLL-rearranged leukaemia cell line, PER-485, treated with small molecule CCI-006.

ABSTRACT: A phenotypic cell-based high-throughput screen identified a novel small molecule, CCI-006 with selective cytotoxic activity against MLL-rearranged leukaemia cell lines. The aim of this experiment was to identify the mechanism of action of CCI-006 by investigating the gene expression changes induced in a MLL-rearranged leukaemia cell line following a short incubation with the compound.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115793 | GEO | 2019/06/01

REPOSITORIES: GEO

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Analysis of gene expression changes in MLL-rearranged leukaemia cell lines with induced resistance against CCI-006

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2019-06-01 | GSE115794 | GEO

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Project description:Analysis of changes in gene expression upon CCI-006 treatment and resistance development of the MLL-rearranged leukaemia cell line PER-485

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Analysis of gene expression changes in MLL-rearranged leukaemia cell lines with induced resistance against CCI-006

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Analysis of changes in gene expression upon CCI-006 treatment and resistance development of the MLL-rearranged leukaemia cell line PER-485

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