Genomics

Dataset Information

44

Expression data from MSCs cultured on 3D and 2D matrixes


ABSTRACT: MSCs in vivo have a markedly different three-dimensioanal (3D) niche compared to the traditional two-dimensional (2D) culture in vitro. We used microarrays to detail the global difference of gene expression between MSCs cultured on 3D and 2D matrixes Overall design: Total RNA from each group (MSCs in 2D surface culture, MSCs in 3D collagen, chitosan, and PLGA matrixes) was analysed using gene microarrays

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Jing Li  

PROVIDER: GSE115947 | GEO | 2018-06-19

REPOSITORIES: GEO

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Publications

Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture.

Li Jing J   Chen Tong T   Huang Xiahe X   Zhao Yunshan Y   Wang Bin B   Yin Yanyun Y   Cui Yi Y   Zhao Yannan Y   Zhang Ruiping R   Wang Xiujie X   Wang Yingchun Y   Dai Jianwu J  

PloS one 20181108 11


Mesenchymal stem cells (MSCs) play important roles in tissue regeneration, and multi-lineage differentiation and immunomodulation are two major characteristics of MSCs that are utilized in stem cell therapy. MSCs in vivo have a markedly different three-dimensional (3D) niche compared to the traditional two-dimensional (2D) culture in vitro. A 3D scaffold is predicted to provide an artificial 3D environment similar to the in vivo environment. Significant changes in MSC differentiation are shown t  ...[more]

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