Transcriptomic analysis of the effect of trastuzumab in human iPSC-CMs

ABSTRACT: We used human iPSC-CMs generated from healthy individuals and performed RNA-sequencing after 7 days of trastuzumab treatment to examine the mechanism associated with contraction dysfunction in iPSC-CMs after trastuzumab treatment. Transcriptome analysis revealed the key role of an altered energy metabolism pathway for cardiomyocytes in the disease pathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116127 | GEO | 2019/09/26

REPOSITORIES: GEO