Genomics,Multiomics

Dataset Information

0

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B cell diffuse large B-cell lymphomas


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): NimbleGen Human Expression Array [2006-10-26_Human_60mer_1in2]

SUBMITTER: SERGIO ROA  

PROVIDER: GSE116290 | GEO | 2019-04-19

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE116290_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image

Publications


Refractory or relapsed diffuse large B-cell lymphoma (DLBCL) often associates with the activated B-cell-like (ABC) subtype and genetic alterations that drive constitutive NF-κB activation and impair B-cell terminal differentiation. Here, we show that DNA damage response by p53 is a central mechanism suppressing the pathogenic cooperation of IKK2ca-enforced canonical NF-κB and impaired differentiation resulting from Blimp1 loss in ABC-DLBCL lymphomagenesis. We provide evidences that the interplay  ...[more]

Similar Datasets

| PRJNA478047 | ENA
2017-05-15 | E-MTAB-4497 | BioStudies
2017-05-15 | E-MTAB-4495 | BioStudies
2012-01-01 | S-EPMC3390034 | BioStudies
2019-01-01 | S-EPMC6769008 | BioStudies
2008-01-01 | S-EPMC2214773 | BioStudies
2015-01-01 | S-EPMC4411286 | BioStudies
2015-01-01 | S-EPMC4542576 | BioStudies
2017-05-15 | E-MTAB-4496 | BioStudies
2006-12-08 | GSE3892 | GEO