Mutation analysis of parental and 10 avirulent C. rodentium isolates from the feces of C3H/HeJ mice

ABSTRACT: We report that dietary iron protects mice from infection by Citrobacter rodentium. Iron induces a state of insulin resistance and increases glucose availability in the gut, thereby attenutating C. rodentium virulence. Additionally the pathogen appears to be driven towards a long-term commensal state. Here, we identify mutations in persistent and avirulent Citrobacter rodentium isolates from mice given an iron supplemented diet.

ORGANISM(S): Citrobacter rodentium

PROVIDER: GSE116595 | GEO | 2018/09/21

REPOSITORIES: GEO