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The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE116602 | GEO | 2018/08/01

REPOSITORIES: GEO

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The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells II

Project description:The naive embryonic stem cells (nESCs) display unique characteristics mirroring naive pluripotency in vivo, but the molecular mechanisms underlying the self-renewal of nESCs remain incompletely understood. Here we analyzed stranded transcriptomes in mouse nESCs and epiblast-like cells (EpiLCs), and identified 135 long non-coding RNAs (lncRNAs) preferentially expressed in nESCs. We further investigated the functions of Lncenc1, a highly abundant lncRNA in mouse nESCs. Knockdown or knockout of Lncenc1 in mouse nESCs leads to significantly decreased expression of core pluripotency genes and significant reduction of colony formation capability. Furthermore, depletion of Lncenc1 down-regulates the glycolysis pathway, as indicated by significant decreases of glycolysis genes expression, glucose consumption, lactate production and Seahorse data. Mechanically, Lncenc1 associates with RNA-binding proteins PTBP1 and HNRNPK functionally. Together, we demonstrate that Lncenc1 regulates the glycolysis in mouse nESCs, suggesting novel functions of lncRNAs in linking energy metabolism and pluripotent stem cells.

2018-08-01 | GSE116462 | GEO

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells I

2018-08-01 | GSE116458 | GEO

A long noncoding RNA regulates sister chromatid cohesion

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-08-03 | E-GEOD-81602 | biostudies-arrayexpress

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells

Project description:The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells

| PRJNA479473 | ENA

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells I

Project description:The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells I

| PRJNA478566 | ENA

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells II

Project description:The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells II

| PRJNA478593 | ENA

Zfp322a regulates mouse ES cell pluripotency and enhances reprogramming efficiency

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-10-31 | E-GEOD-45140 | biostudies-arrayexpress

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.

Project description: Not available

| S-EPMC6135739 | biostudies-literature

A long noncoding RNA regulates sister chromatid cohesion

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-08-03 | GSE81602 | GEO

Long noncoding RNA INCA1 regulates tumor interferon signaling.

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-29 | GSE137489 | GEO

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