Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of eight lymphoblastoid cell lines after AHR ligand treatments

ABSTRACT: RNA-seq was done on eight different lymphoblastoid cell lines for vehicle control, 3-MC agonist treatment and GNF-351 antagonist treatment for AHR to look at AHR regulated genes with different genetic backgrounds. We identified 69 genes that were highly differentially expressed after 3-MC or GNF-351 antagonist treatment with variation in the degree fo differential expression between the eight cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116637 | GEO | 2018/07/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

AHR ChIP-seq in lymphoblastoid cell line

Project description:ChIP-seq was done on one lymphoblastoid cell lines for vehicle control, or 3-MC agonist treatment to identify AHR binding regions throughout the genome. We identified 17,688 common binding peaks between all ChIP treatments

2018-07-06 | GSE116632 | GEO

RNA-seq of eight lymphoblastoid cell lines after AHR ligand treatments

Project description:RNA-seq of eight lymphoblastoid cell lines after AHR ligand treatments

| PRJNA479764 | ENA

AhR antagonist

Project description:AhR antagonist

| PRJNA766233 | ENA

eight coral species

Project description:eight coral species Transcriptome or Gene expression

| PRJNA377358 | ENA

Analysis of RNA expression under AhR antagonist treatment in human HSPCs

Project description:Analysis of RNA expression under AhR antagonist treatment in human HSPCs

| PRJNA766235 | ENA

Analysis of RNA expression under AhR antagonist treatment in human HSPCs

Project description:To examine the changes in RNA expression profile under AhR antagonist treatment in human hematopoietic stem progenitor cells (HSPCs), CD34+cells were isolated from umbilical cord blood (UCB) unit. CD34+cells were cultured with two different AhR antagonists CH223191 and StemRegenin1 (SR1) ex vivo for 7 days. cultured cells were used to perform RNA sequencing and analyze the changes in RNA expression profile by treatment.

2022-06-01 | GSE184779 | GEO

Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.

Project description:Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.

| PRJNA595589 | ENA

RNA-Seq analysis of primary AML specimens exposed to AhR modulating agents

Project description:The goal of the study was to identify genes that are directly or indirectly coregulated by the AhR pathway in primary human AML cells. Patient AML cells were treated for 16 hours with the two indirubin derivatives 6-bromoindirubin-3'oxime (BIO), 1-Methyl-6-bromoindirubin-3'oxime (MeBIO), the AHR-antagonist SR1 (StemReginin1), combinations of BIO+SR1 and MeBIO+SR1 or DMSO alone at indicated concentrations prior to RNA extraction for sequencing. RNA-Seq performed on 5 primary AML samples fresh (t0) and after exposure to AhR-agonists (2), -antagonist (1), and DMSO Contributor: Leucegene Project, IRIC

2016-07-20 | E-GEOD-48843 | biostudies-arrayexpress

Expression profiling of the effect of treatment with GNF-7 on mutant NRAS-positive leukemia cell lines

Project description:The complexity of RAS signaling makes targeting RAS challenging. We therefore hypothesized that inhibiting a combination of downstream targets of RAS may potentially lead to an effective therapeutic intervention. We performed a high-throughput chemical screen using a library consisting of multi-targeted inhibitors with the expectation that one or more inhibitors would likely- due to their broad spectrum inhibitory potential- hit critical targets of mutant NRAS. We identified GNF-7, a multi-targeted kinase inhibitor that proved to have high selectivity and sensitivity for leukemia cells with NRAS mutations both in vitro and in vivo. We used microarrays to determine which transcripts were affected by treatment with GNF-7. We selected a single comparative timepoint, 8 hours post-treatment with GNF-7. GSEA (gene set enrichment analysis) was performed using gene signatures in MSigDB (Molecular Signatures Database) for analysis. This led to the identification of MYC-network genes as being the downstream conduit of the effect of this treatment. We also found that treatment with GNF-7 abolished

2015-12-01 | GSE49534 | GEO

Eight shrimp farm soil sediment metagenomes

Project description:Eight shrimp farm soil sediment metagenomes

| PRJNA809862 | ENA