Transcriptomics

Dataset Information

0

BORG-dependent alterations in the transcriptome of D2.OR cells


ABSTRACT: The ubiquitous nature of lncRNAs to comprehensively alter cellular transcriptional networks led us to hypothesize that BORG is capable of compelling metastasic, chemoresistant, and pro-survival activities in triple-negative breast cancers by inducing global transcriptomic reprogramming. As such, we performed RNA-seq to garner mechanistic insights into BORG-dependent pathways within D2.OR cells. Accordingly, transcriptional profiles associated with aggressive breast cancers and adaptive survival programs were amongst the top enriched pathways in BORG-expressing D2.OR cells. Most notably, BORG enriched for gene signatures that were critical for the development of chemoresistance towards doxorubicin, as well as a core set of genes upregulated in response to hypoxia, radiotherapy, and serum-deprivation.

ORGANISM(S): Mus musculus

PROVIDER: GSE116656 | GEO | 2019/03/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-05-28 | E-GEOD-81971 | biostudies-arrayexpress
2017-08-30 | GSE99234 | GEO
2021-11-10 | GSE188404 | GEO
2016-05-28 | GSE81971 | GEO
2020-02-25 | E-MTAB-8787 | biostudies-arrayexpress
| PRJNA196226 | ENA
2022-09-20 | GSE206242 | GEO
2014-01-17 | GSE54175 | GEO
2014-01-17 | E-GEOD-54175 | biostudies-arrayexpress
2013-12-31 | E-GEOD-47013 | biostudies-arrayexpress