BORG-dependent alterations in the transcriptome of D2.OR cells

ABSTRACT: The ubiquitous nature of lncRNAs to comprehensively alter cellular transcriptional networks led us to hypothesize that BORG is capable of compelling metastasic, chemoresistant, and pro-survival activities in triple-negative breast cancers by inducing global transcriptomic reprogramming. As such, we performed RNA-seq to garner mechanistic insights into BORG-dependent pathways within D2.OR cells. Accordingly, transcriptional profiles associated with aggressive breast cancers and adaptive survival programs were amongst the top enriched pathways in BORG-expressing D2.OR cells. Most notably, BORG enriched for gene signatures that were critical for the development of chemoresistance towards doxorubicin, as well as a core set of genes upregulated in response to hypoxia, radiotherapy, and serum-deprivation.

ORGANISM(S): Mus musculus

PROVIDER: GSE116656 | GEO | 2019/03/27

REPOSITORIES: GEO