Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

ABSTRACT: To explore the lncRNA landscape of periodontal ligament stem cells (PDLSCs) subjected to compressive force.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116787 | GEO | 2021/07/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional profiling of immortalized human periodontal ligament cells subjected to compressive force

Project description:An immortalized human periodontal ligament cell line derived from cementifying fibroma cells was cultured in vitro and subjected to compressive force for 24 hours or maintained as untreated controls. Bulk RNA sequencing using a 3′ mRNA-seq (QuantSeq) approach was performed to characterize transcriptional responses to mechanical compression.

2026-04-03 | GSE315426 | GEO

Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

Project description:Mechanical force has been shown to regulate periodontal ligament cells (PDLs) behaviors. However, different force types lead to distinct PDLs’ responses. Here, the differential gene expression profiling of PDLs subjected to static and intermittent compressive forces was examined using RNA sequencing technique. Results demonstrated that the static and intermittent compressive force treated PDLs exhibited the differential regulation genes. KEGG pathway enrichment analysis revealed that focal adhesion and transforming growth factor beta signaling pathway were commonly upregulated while calcium signaling pathway was downregulated in both static and intermittent compressive force-treated PDLs. Interestingly, Wnt signaling pathway was upregulated only in the PDLs that subjected to the intermittent compressive force.

2019-07-23 | GSE112122 | GEO

Transcriptional profiling of immortalized human periodontal ligament cells subjected to compressive force

Project description:Transcriptional profiling of immortalized human periodontal ligament cells subjected to compressive force

| PRJNA1397141 | ENA

The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

Project description:The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

| PRJNA480245 | ENA

Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

Project description:Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

| PRJNA439381 | ENA

Differential miRNA expression of healthy and inflammatory periodontal ligament stem cells-derived exosomes

Project description:To further explore the specific expressed miRNA in healthy and inflammatory periodontal ligament stem cells (PDLSCs)-derived exosomes, we extracted their exosomal RNA for miRNA microarray assay.

2021-04-01 | GSE163489 | GEO

Proteomic Profiling of PTEN Inhibition on Periodontal Ligament Stem Cells

Project description:: Phosphatase and tensin homolog (PTEN) is a critical regulator of cell proliferation, differentiation, and inflammatory balance. However, its downstream proteomic effects in periodontal ligament stem cells (PDLSCs) remain poorly understood. This study aimed to elucidate the proteomic alterations induced by PTEN inhibition and identify potential molecular pathways underlying periodontal regeneration.

2026-03-30 | PXD074161 | Pride

The effect of PTEN inhibitor on Periodontal ligament cells

Project description:Objective: Phosphatase and Tensin Homolog (PTEN) act as a negative regulator of the phosphatidylinositol-3-kinase (PI3k)/Akt pathway, which is involved in cell growth, cell proliferation, differentiation, and survival signaling. This study aimed to investigate the effects of VO-OHpic, a PTEN inhibitor, on periodontal ligament stem cells (PDLSCs).

2025-04-20 | GSE295018 | GEO

Transcriptional Expression in Human Periodontal Ligament Cells Subjected to Orthodontic Force: An RNA-Sequencing Study

Project description:Purpose : This study was performed to investigate the changes in gene expression in periodontal ligament (PDL) cells following mechanical stimulus through RNA sequencing. Method : Premolars extracted for orthodontic treatment were used. To stimulate the PDL cells, an orthodontic force of 100× g was applied to the premolar (experimental group; n = 11), whereas the tooth on the other side was left untreated (control group; n = 11). After the PDL cells were isolated from the extracted teeth, gene set enrichment analysis (GSEA), differentially expressed gene (DEG) analysis, and real-time PCR were performed to compare the two groups. Result : GSEA demonstrated that gene sets related to the cell cycle pathway were upregulated in PDL. Thirteen upregulated and twenty downregulated genes were found through DEG analysis. Real-time PCR results confirmed that five upregulated genes (CC2D1B, CPNE3, OPHN1, TANGO2, and UAP-1) and six downregulated genes (MYOM2, PPM1F, PCDP1, ATP2A1, GPR171, and RP1-34H18.1-1) were consistent with RNA sequencing results. Conclusion : Two upregulated genes, CPNE3 and OPHN1, and one downregulated gene, PPM1F, play an important role in PDL regeneration in humans when orthodontic force is applied.

2021-02-03 | GSE165988 | GEO

Comprehensive analysis of M2 macrophage-derived exosomes facilitating osteogenic differentiation of human periodontal ligament stem cells

Project description:As the primary seed cells in periodontal tissue engineering, the role of periodontal ligament stem cells (PDLSCs) in periodontal tissue regeneration and bone remodeling during orthodontic tooth movement (OTM) has been well documented. Nevertheless, the impact of different polarization states of macrophages on the osteogenic differentiation of PDLSCs is poorly understood. M0, M1 and M2 macrophage-derived exosomes (M0-exo, M1-exo and M2-exo) were treated with primary cultured human PDLSCs, respectively. Identification of differentially expressed microRNAs (DE-miRNA) in M0-exo and M2-exo by miRNA microarray. In summary, we have indicated for the first time that M2-exo can promote osteogenic differentiation of human PDLSCs, and have revealed the functions and pathways involved in the DE-miRNAs of M0-exo and M2-exo and their downstream targets.

2022-10-31 | GSE209957 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data