Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)
ORGANISM(S): Homo sapiens
SUBMITTER: YEQIAO ZHOU
PROVIDER: GSE116875 | GEO | 2019-02-27
REPOSITORIES: GEO
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GSE116875_RAW.tar | Raw | |||
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Petrovic Jelena J Zhou Yeqiao Y Fasolino Maria M Goldman Naomi N Schwartz Gregory W GW Mumbach Maxwell R MR Nguyen Son C SC Rome Kelly S KS Sela Yogev Y Zapataro Zachary Z Blacklow Stephen C SC Kruhlak Michael J MJ Shi Junwei J Aster Jon C JC Joyce Eric F EF Little Shawn C SC Vahedi Golnaz G Pear Warren S WS Faryabi Robert B RB
Molecular cell 20190207 6
Chromatin loops enable transcription-factor-bound distal enhancers to interact with their target promoters to regulate transcriptional programs. Although developmental transcription factors such as active forms of Notch can directly stimulate transcription by activating enhancers, the effect of their oncogenic subversion on the 3D organization of cancer genomes is largely undetermined. By mapping chromatin looping genome-wide in Notch-dependent triple-negative breast cancer and B cell lymphoma, ...[more]