Dataset Information


Time-course inducible NOTCH3-IC expression in SH-SY5Y.

ABSTRACT: Expression analysis of ADRN cell line SH-SY5Y with doxycycline-inducible NOTCH3-IC was used to study transcriptional reprogramming to a MES state. Overall design: Cells were induced with doxycycline for a time-course of 1-7-14-21 days to analyze mRNA.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo Sapiens

SUBMITTER: Rogier Versteeg  

PROVIDER: GSE116890 | GEO | 2019-04-04


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Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES) tumor cell types, which differ in phenotype, super-enhancers (SEs) and core regulatory circuitries. These cell types can spontaneously interconvert, but the mechanism remains largely unknown. Here, we unravel how a NOTCH3 intracellular domain repro  ...[more]

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