PRMT5 Interacts with the BCL6 Oncoprotein and is Required for Germinal Center Formation and Lymphoma Cell Survival

ABSTRACT: We have found that PRMT5 methylates BCL6 and is needed for its full transcriptional repressor activity. Concomitant inhibition of both BCL6 and PRMT5 exhibits synergistic killing of BCL6-expressing lymphoma cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE116963 | GEO | 2018/12/06

REPOSITORIES: GEO