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RNA-seq in normal human dermal fibroblast cells for understanding protective effects of visible red light (660nm) in response to UVB (312nm) exposure

ABSTRACT: The aim of this study is identifying potential signaling pathways involve with visible red light induced photoprotective effect against skin damage by UVB exposure, using transcriptomic analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE116968 | GEO | 2021/06/20

REPOSITORIES: GEO

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RNA-seq in normal human dermal fibroblast cells for understanding protective effects of visible red light (660nm) in response to UVB (312nm) exposure

Project description:RNA-seq in normal human dermal fibroblast cells for understanding protective effects of visible red light (660nm) in response to UVB (312nm) exposure

| PRJNA480708 | ENA

Effect of visible light on human skin fibroblasts

Project description:Artificial visible light is everywhere in our modern life. Our mode of social communication confronts us with screens of all kinds and their use is on the rise. People are therefore increasingly exposed to artificial visible light of which effects on skin are still largely poorly known. The purpose of this study was to model the artificial visible light emitted by electronic devices and subsequently assess the effect of such a light in normal human fibroblasts.

2018-06-30 | GSE112614 | GEO

UV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB

Project description:To test whether there is a photoprotective benefit after different types of suberythemal repetitive UV, a 1.5 MED challenge dose was applied 1 week after the initial 2 weeks of repetitive irradiation. To determine what different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific proteins and paracrine melanogenic factors are regulated by repetitive exposure to suberythemal doses of different types of UV (UVA and/or UVB). Seven volunteers with skin type II-III were irradiated with UVA, UVB or UVA+UVB radiation for 2 weeks (5 times per week, 10 times total) after preliminary determination of their MEDs. A UVA+UVB challenge dose of 1.5X the MED was applied 1 week later. Biopsies were taken before the challenge dose, immediately after the challenge dose, 4 days after the challenge, and 15 weeks after the challenge.

2014-12-12 | E-GEOD-56754 | biostudies-arrayexpress

Effect of visible light on human skin fibroblasts

Project description:Effect of visible light on human skin fibroblasts

| PRJNA448517 | ENA

UV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB

2014-12-12 | GSE56754 | GEO

Skin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior

Project description:Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in enhanced ovary size, extended estrus days, and anti-Mullerian hormone (AMH) expression. It likewise enhances the sexual responsiveness and attractiveness of females and male-female interactions of both males and females. Conditional knockout of p53 specifically in skin keratinocytes abolished UV’s effects. In humans, UV exposure enhanced romantic passion in both genders increased testosterone levels in men. Our data, revealing that UVB triggers a skin-brain-gonadal axis through skin p53 activation, offers therapeutic opportunities for sex-steroid-related dysfunctions. We speculate that during human furless skin evolution, the skin became the front-line regulator of the response to UVB.

2022-02-17 | PXD025973 | Pride

Bioprinting of Injectable Centimeter-scale Architectures with a Visible-light Crosslinking Bioink

Project description:This study propose a novel visible-light crosslinking hydrogel bioink (termed GP) to fabricate injectable centimeter-scale architectures. Composed of GelMA with large molecular weight PEGDA, GP can form a reinforced dual-crosslinking network, presenting excellent superelasticity and stability, supporting injection pass nozzles with 1.5mm inner diameter after bioprinted as 15mm×15mm scale architectures. Moreover, when printing with living cells, even for sensitive cell lines like genome-edited cells, the transcriptome of cells after printing shows no difference, suggesting the high cell printing suitability of GP and the visible-light extrusion printing technique. The printed architectures can support long-term culture for at least 14 days, and GP provides cells with a biocompatible microenvironment, supporting cell survival, proliferation, and function maintenance.

2023-10-19 | GSE230068 | GEO

Effect of visible light on the transcriptome of Clostridium autoethanogenum during gas fermentation

Project description:The expression profile of C. autoethanogenum DSM 10061 grown autotrophically with H2:CO:CO2 under visible light at an intensity of 4200 lux versus the expression profile of C. autoethanogenum DSM 10061 grown autotrophically in the dark

2023-07-01 | GSE207468 | GEO

Study of UVB responses of SV40 transformed human lung fibroblast: Control vs. UVB irradiated

Project description:Previous studies showed that SV40 transformed cells have unique DNA damage responses; further inspecting these responses by microarray provides an opportunity to discover transciprtional insights of DNA damage responses after UVB irradiation. This study is used to comapre to GSE7589, our previous study of human normal lung fibroblast after UVB irradiation. We used a loop design in this study, cDNA microarray experiment consisted of eight RNA samples, including UVB-irradiated samples and their corresponding controls of 4 time points after UV irradiation.

2013-06-30 | E-GEOD-41319 | biostudies-arrayexpress

Study of UVB responses of SV40 transformed human lung fibroblast: Control vs. UVB irradiated

2013-06-30 | GSE41319 | GEO

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