Identification of differentially expressed genes between control and PIK3CD GOF human activated transitional B cells

ABSTRACT: IL-21 induces B cell activation, and differentiation into antibody-secreting plasmblasts in vitro. This process is compromised in transitional B cells to gain of function mutations in PIK3CD We used microarrays to identify genes that are differentiatlly expressed following CD40L/IL-21 stimulation of human transitonal B cells from healthy donors and patients with GOF mutations in PIK3CD

ORGANISM(S): Homo sapiens

PROVIDER: GSE116999 | GEO | 2018/07/13

REPOSITORIES: GEO