RNA sequencing of isogenic Phf6 wild type and Phf6 knockout mouse T-ALL cells

ABSTRACT: Loss-of-function mutations Phf6 occur frequently in both adult and pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL). Although Phf6 is widely expressed, little is known about its proposed function as epigenetic regulator and tumor suppressor. To address the role of Phf6 in the leukemia development, here we analyze by RNAseq the gene expression profiles of isogenic Phf6 wild type and Phf6 knockout leukemia cells transformed by overexpression of an oncogenic mutant form of the NOTCH1 receptor.

ORGANISM(S): Mus musculus

PROVIDER: GSE117165 | GEO | 2019/07/31

REPOSITORIES: GEO