Transcriptomics

Dataset Information

0

Transcriptomic profile of single-cell sorted monocytes, T cells and CD3+CD14+ cells from one subject infected with latent tuberculosis


ABSTRACT: We set out to detect a transcriptional signature in CD4 T cells of individuals at risk of progression to active tuberculosis. We indeed found such a signature which surprisingly could be tracked to a cell population expressing both T cell (CD3) and monocyte (CD14) markers. To identify the nature of the CD3+CD14+ population, we determined the transciptomic profile of single cells CD3-CD14+ Monocytes (n=21), CD3+D14- T cells (n=22), CD3+CD14+ cells in the Monocyte gate (Mgate) (n=22) and CD3+CD14+ cells in the lymphocyte gate (Lgate) (n=20) from one subject infected with latent tuberculosis by RNA sequencing. PCA on all genes showed that CD3+CD14+ cells represent an intermediate population between Monocytes and T cells, with CD3+CD14+ L gate cells closer to T cells compared to CD3+CD14+ Mgate cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117435 | GEO | 2021/07/08

REPOSITORIES: GEO

Similar Datasets

2023-09-01 | GSE229707 | GEO
2011-07-24 | E-GEOD-30811 | biostudies-arrayexpress
2016-02-18 | E-GEOD-64385 | biostudies-arrayexpress
2011-07-24 | GSE30811 | GEO
2016-02-18 | GSE64385 | GEO
2014-08-29 | E-GEOD-57736 | biostudies-arrayexpress
2015-06-27 | E-GEOD-70327 | biostudies-arrayexpress
2023-01-02 | GSE214237 | GEO
2022-05-16 | GSE176079 | GEO
2015-06-27 | GSE70327 | GEO