RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

ABSTRACT: The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze by RNAseq the gene expression profile of DN3 thymocytes from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice. GSEA analysis show a significant enrichment of MYC signature genes, consistent with a deficient function of NMe in GATA site 1 and 2 homozygous mutant thymocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE117483 | GEO | 2019/08/01

REPOSITORIES: GEO