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SMAD2 binding regions in breast cancer cell line and RNA-seq transcriptome analyses in T47D

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117502 | GEO | 2018/10/23

REPOSITORIES: GEO

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SMAD2 binding regions in estrogen receptor-positive breast cancer cell line, T47D

Project description:Inhibitors for cyclin-dependent kinase (CDK) 4 and CDK6 have been established as effective therapeutic options for hormone receptor (HR)-positive, HER2-negative advanced breast cancer. Although the CDK4/6 inhibitors mainly target the cyclin D-CDK4/6-retinoblastoma tumor suppressor protein (RB) axis, little is known about clinical impact of inhibiting phosphorylation of other CDK4/6 target proteins. Here, we have focused on other CDK4/6 targets, SMAD proteins. We showed that a CDK4/6 inhibitor Palbociclib and Activin-SMAD2 signaling cooperatively inhibited cell cycle progression of a luminal-type breast cancer cell line T47D. Mechanistically, Palbociclib enhanced SMAD2 binding to the genome through inhibiting linker phosphorylation of the SMAD2 protein by CDK4/6. Comparison of the SMAD2 ChIP-seq data of T47D with those of a triple-negative breast cancer cell line Hs578T indicated that Palbociclib augments different SMAD2-mediated program defined based on types of cells, and enhances SMAD2 binding to the target regions on the genome without affecting its binding pattern. Collectively, the CDK4/6 inhibitor facilitates the cytostatic effects of Activin-SMAD2, while it also enhances its tumor promoting effects depending on types of breast cancer.

2018-10-23 | GSE117495 | GEO

SMAD2 binding regions in breast cancer cell line and RNA-seq transcriptome analyses in T47D

Project description:SMAD2 binding regions in breast cancer cell line and RNA-seq transcriptome analyses in T47D

| PRJNA482337 | ENA

SMAD2 binding regions in estrogen receptor-positive breast cancer cell line, T47D

Project description:SMAD2 binding regions in estrogen receptor-positive breast cancer cell line, T47D

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SMAD2 binding regions in triple negative breast cancer cell line, Hs578T

2018-10-23 | GSE117496 | GEO

SMAD2 binding regions in triple negative breast cancer cell line, Hs578T

Project description:SMAD2 binding regions in triple negative breast cancer cell line, Hs578T

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Apoptosis induction on human breast cancer T47D cell line by extracts of Ancorina sp.

Project description: Not available

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Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7.

Project description: Not available

| S-EPMC3286449 | biostudies-literature

Inhibition of hTERT Gene Expression by Silibinin-Loaded PLGA-PEG-Fe3O4 in T47D Breast Cancer Cell Line.

Project description: Not available

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aCGH hybridization of breast cancer cell line T47D

Project description:An array CGH hybridization of breast cancer cell line T47D compared against a normal human female reference.

2010-06-25 | GSE22547 | GEO

T47D Breast cancer cell line ChIP-seq data

Project description:We performed genome-wide PADI2 ChIP seq experiments in T47D cell lines and also RNP2 ChIP seq in T47D cells only expressing HA Tagged amanitin resistant wild type in comparison to R1810A mutant form of RNAP2.

2018-11-21 | GSE105793 | GEO

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