Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

ABSTRACT: The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze chromatin accessibility by ATACseq in DN3 thymocytes and Notch-induced TALL blasts from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE117573 | GEO | 2019/08/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze by RNAseq the gene expression profile of DN3 thymocytes from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice. GSEA analysis show a significant enrichment of MYC signature genes, consistent with a deficient function of NMe in GATA site 1 and 2 homozygous mutant thymocytes.

2019-08-01 | GSE117483 | GEO

ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

| PRJNA482545 | ENA

Single-cell RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous thymocytes

2021-07-18 | GSE117412 | GEO

RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

| PRJNA482314 | ENA

Role of GATA in DN3 stage thymocytes

Project description:RNA-seq in DN3 stage thymocytes isolated from wild type and Gata3 hypomorphic mutant mouse

2018-06-14 | GSE115739 | GEO

Role of GATA in DN3 stage thymocytes

Project description:Role of GATA in DN3 stage thymocytes

| PRJNA475907 | ENA

Chromatin accessibility and transcriptomic profiling in NMe Gata-site double mutant mouse DN3 Thymocytes

Project description:Chromatin accessibility and transcriptomic profiling in NMe Gata-site double mutant mouse DN3 Thymocytes

| PRJNA482677 | ENA

Role of Tcf-1 (Tcf7) in DN3 thymocytes

Project description:Comparison of wild-type and Tcf-1-deficient DN3 thymocytes

2021-11-01 | GSE93346 | GEO

Identification of the molecular targets of miR-185 in DN3 stage thymocytes

Project description:T cell-specific overexpression of miR-185 caused a developmental block at DN3 stage of thymopoiesis. DN3 stage thymocytes were sorted from the wild type (C57BL/6) and miR-185 Tg mice, followed by total RNA isolation.

2013-10-28 | E-GEOD-49057 | biostudies-arrayexpress

Identification of the molecular targets of miR-185 in DN3 stage thymocytes

Project description:T cell-specific overexpression of miR-185 caused a developmental block at DN3 stage of thymopoiesis.

2013-10-28 | GSE49057 | GEO