Transcriptional changes in mouse models in SCA3

ABSTRACT: The study examined early transcriptional changes in the brain of different mouse models of spinocerebellar ataxia type 3, a dominantly-inherited neurodegenerative disease caused by a CAG repeat expansion in the ATXN3 gene. The goal was to identify early transcriptional signatures that are strongly associated with the accumulation and aggregation of the disease protein, ataxin-3, in the brain. The study also investigated the extent to which the observed transcriptional changes might be contributors to disease pathogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE117605 | GEO | 2018/07/25

REPOSITORIES: GEO