Investigating the role of SMCHD1 in regulating the chromatin states of select autosomal gene clusters

ABSTRACT: To investigate the effect of Smchd1 ablation on the chromatin states of select autosomal gene clusters, we derived clonal neural progenitor cells (NPCs) from Smchd1+/+ (wild-type, WT) and Smchd1-/- mouse embryonic stem cells (ES cells; ESC). We generated allele-specific EZH2 ChIP-seq datasets from WT and Smchd1-/- NPCs to examine the effect of Smchd1 ablation on the distribution of Polycomb repressive complex 2 (PRC2).

ORGANISM(S): Mus musculus

PROVIDER: GSE117636 | GEO | 2021/07/23

REPOSITORIES: GEO