P38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress

ABSTRACT: Alternative splicing is a crucial mechanism for gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has a major impact on the regulation of alternative splicing (AS), which is partly mediated through the action of the p38 SAPK. Remarkably, a splicing network analysis revealed a functional connection between p38 and the spliceosome component SKIIP. Depletion of SKIIP abolished a significant part of the p38-mediated alternative splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117699 | GEO | 2019/04/16

REPOSITORIES: GEO