Transcriptomics

Dataset Information

27

Estrogen- and Myc-regulated genes in MCF-7 breast cancer cells


ABSTRACT: Estrogen-responsive genes were identified by transcript profiling of estrogen-treated MCF-7 breast cancer cells. The gene expression profile generated after estrogen treatment was compared with that following inducible expression of c-Myc or c-Zip (a deletion mutant of c-Myc that lacks the N-terminal transactivation domains) in clonal MCF-7 cell lines. Keywords: Single time point Overall design: RNA was collected in three independent experiments, each including parental MCF-7 cells treated with 17b-estradiol (E2) or ethanol (EtOH), zinc-treated p∆MT-c-Myc cells, zinc-treated p∆MT-c-Zip cells and zinc-treated empty vector (p∆MT) cells. Cells were arrested for 48 h with 10 nM ICI 182780 and then treated for 6 h with either 100 nM E2 or ethanol vehicle, or 75 mM zinc for the stably transfected cell lines.

REANALYSED by: GSE119128

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Liz Musgrove  

PROVIDER: GSE11791 | GEO | 2008-08-21

SECONDARY ACCESSION(S): PRJNA105991

REPOSITORIES: GEO

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