Angiotensin Converting Enzyme Inhibition Attenuates Interstitial Injury in a Murine Model of Chronic Glomerulonephritis

ABSTRACT: This study examined the role of local complement synthesis in a mouse model of glomerulonephritis, which evolves into progressive tubulointerstitial disease. The model was used to quantitate clinical, histologic, and transcriptomic outcomes, and assess the role of angiotensin conversting enzyme (ACE) inhibition in modifying these measures. We also comprehensively explored the biological pathways and networks exhibiting alterations in gene expression to provide further insight into the role of ACE inhibition in the model.

ORGANISM(S): Mus musculus

PROVIDER: GSE117917 | GEO | 2018/08/01

REPOSITORIES: GEO