ChIP-seq of ER in MCF-7 cells post ligand treatment

ABSTRACT: Goal: study the impact of estrogen receptor (ER) ligands on ER binding to chromatin in MCF-7 cells Methods: ER Chromatin Immunoprecipitation and Sequencing (ChIP-seq) Results: All tested ligands increase binding of ER onto DNA in MCF-7 breast cells. These ligands thus promote an association between ER and DNA, irrespective of their mode of action: selective ER modulator (SERM) 4-OH tamoxifen, and selective ER degraders (SERD) fulvestrant and GDC-0927.

ORGANISM(S): Homo sapiens

PROVIDER: GSE117941 | GEO | 2019/07/25

REPOSITORIES: GEO